Biography

Dr. Mark Cascione is a board-certified neurologist who has dedicated his career to caring for people with Multiple Sclerosis (MS) and other neurological conditions. Originally from Jackson, New Jersey, he began his medical journey with a strong foundation in science and research, including early work at Massachusetts General Hospital. In 1996, Dr. Cascione founded Tampa Neurology Associates, and later established the South Tampa MS Center to provide focused, compassionate care for individuals living with MS. He is known for taking the time to listen to his patients, helping them understand their condition, and working closely with them to create personalized treatment plans. In addition to his clinical work, Dr. Cascione has been deeply involved in advancing MS care through research. He has participated in over 300 clinical trials as a principal investigator or sub-investigator, giving his patients access to cutting-edge therapies and contributing to progress in MS treatment.

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Credentials

Fellowship

Duke University Medical Center, Clinical Neurophysiology (1995–1996)

Residency

Duke University Medical Center, Neurology (1992–1995)

Internship

Maine Medical Center, Internal Medicine (1991–1992)

Medical Education

University of Vermont College of Medicine (1991)

Board Certifications

American Board of Psychiatry and Neurology — Neurology

Honors and Awards

Tampa Top Docs 2017, 2018, 2019, 2020 (Tampa Magazine)

Hobbies & Interests

Outside of his professional life, Dr. Cascione enjoys spending time with his family and was married in 2015.

What Our Patients Have to Say

I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.

Dolly B.

Patient of

Mark Cascione, M.D.

I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.

Judith M.

Patient of

Mark Cascione, M.D.

Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.

Lupe S.

Patient of

Mark Cascione, M.D.

Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.

Ellen S.

Patient of

Mark Cascione, M.D.

My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.

Sally D.

Patient of

Mark Cascione, M.D.

I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.

Dolly B.

Patient of

Mark Cascione, M.D.

I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.

Judith M.

Patient of

Mark Cascione, M.D.

Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.

Lupe S.

Patient of

Mark Cascione, M.D.

Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.

Ellen S.

Patient of

Mark Cascione, M.D.

My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.

Sally D.

Patient of

Mark Cascione, M.D.

I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.

Dolly B.

Patient of

Mark Cascione, M.D.

I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.

Judith M.

Patient of

Mark Cascione, M.D.

Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.

Lupe S.

Patient of

Mark Cascione, M.D.

Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.

Ellen S.

Patient of

Mark Cascione, M.D.

My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.

Sally D.

Patient of

Mark Cascione, M.D.

I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.

Dolly B.

Patient of

Mark Cascione, M.D.

I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.

Judith M.

Patient of

Mark Cascione, M.D.

Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.

Lupe S.

Patient of

Mark Cascione, M.D.

Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.

Ellen S.

Patient of

Mark Cascione, M.D.

My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.

Sally D.

Patient of

Mark Cascione, M.D.

I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.

Dolly B.

Patient of

Mark Cascione, M.D.

I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.

Judith M.

Patient of

Mark Cascione, M.D.

Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.

Lupe S.

Patient of

Mark Cascione, M.D.

Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.

Ellen S.

Patient of

Mark Cascione, M.D.

My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.

Sally D.

Patient of

Mark Cascione, M.D.

I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.

Dolly B.

Patient of

Mark Cascione, M.D.

I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.

Judith M.

Patient of

Mark Cascione, M.D.

Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.

Lupe S.

Patient of

Mark Cascione, M.D.

Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.

Ellen S.

Patient of

Mark Cascione, M.D.

My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.

Sally D.

Patient of

Mark Cascione, M.D.

Contact Us

Whether you're newly diagnosed, looking for a second opinion, or just want to learn more about us, someone from our team can reach out to you to share more information about MS & Neuromuscular Center of Excellence (MSN)
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I have been to a few neurologists in the area and this is the best. I've seen both Dr. Schneider and ARNP Dawn Rush-Wilde. They never make me feel rushed and always listen to my concerns. The office staff is also helpful and nice. I know that several staff members are bilingual, but speak English very clearly. If you're looking for a neurologist, I highly recommend this office.

Becky K.

Patient

I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.

Holly G.

Patient

Location

3190 N McMullen Booth Road, Suite 200, Clearwater, FL 33761

Phone:

1-813-855-2900

Hours:

Monday: 7:45am – 5pm

Tuesday: 7:45am – 5pm

Wednesday: 7:45am – 5pm

Friday: 7:45am – 3:30pm

Saturday: Closed

Sunday: Closed

We are in-network with all major insurance plans in the greater Tampa Bay area